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KMID : 0848120170420020039
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International Journal of Oral Biology
2017 Volume.42 No. 2 p.39 ~ p.45
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Effect of Metformin on Cell Growth and Differentiation in Cultured Odontoblasts
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Oh Chang-Young
Kim Su-Gwan
Go Dae-San
Yu Sun-Kyoung
Kim Tae-Hoon
Park Joo-Cheol
Kim Do-Kyung
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Abstract
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Metformin (1,1-dimethylbiguanide hydrochloride), derived from French lilac (Galega officinalis), is a first-line anti-diabetic drug prescribed for patients with type 2 diabetes. However, the role of metformin in odontoblastic cell differentiation is still unclear. This study therefore undertook to examine the effect of metformin on regulating odontoblast differentiation in MDPC-23 mouse odontoblastic cells derived from mouse dental papilla cells. As compared to controls, metformin significantly accelerated the mineralization, significantly increased and accelerated the expressions of ALP and Col I mRNAs, and significantly increased the accelerated expressions of DSPP and DMP-1 mRNAs, during differentiation of MDPC-23 cells. There was no alteration in cell proliferation of MDPC-23 cells, on exposure to metformin. These results suggest that the effect of metformin on MDPC-23 mouse odontoblastic cells derived from mouse dental papilla cells, facilitates the odontoblast differentiation and mineralization, without altering the cell proliferation.
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KEYWORD
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metformin , odontoblasts , differentiation , mineralization
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